Reconstructable Uterus‐Derived Materials for Uterus Recovery toward Efficient Live Births. Issue 8 (20th January 2022)

• Record Type: Journal Article
• Authors: Yi, Xiao; Liu, Fan; Gao, Kunjie; Chen, Feng; Wang, Yifeng; Li, Huayan; Wang, Xuefeng; Huang, Yi; Fu, Huijiao; Zhou, Weijie; Fan, Jun‐Bing; Wang, Shutao; Gao, Yi
• Is Part Of: Advanced materials. Volume 34:Issue 8(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-20
• Subjects: live births -- mesenchymal stem cells -- reconstructable uterus‐derived materials -- uterus recovery; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202106510
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Uterine factor infertility is increasingly common in modern society and has severely affected human life and health. However, the existing biomaterial scaffold‐mediated systems remain limited in efficient uterus recovery, leading to low pregnancy rate and live births. Here, reconstructable uterus‐derived materials (RUMs) are demonstrated by combining uterus‐derived extracellular matrix and seeded chorionic villi mesenchymal stem cells for uterus recovery, achieving highly efficient live births in rats with severe uterine injury. The RUMs can be designed into different states (such as, liquid RUMs and solid RUMs) and shapes (such as, cuboid, triangular‐prism, and cube) in terms of requirements. The RUMs can effectively prevent intrauterine adhesion, and promote endometrial regeneration and muscle collagen reconstruction, as well as, accelerate wound healing by constructing a physical barrier and secreting cytokines, allowing efficient uterus recovery. The injured uterus nearly achieves complete recovery after treating with the RUMs and has normal pregnancies for supporting fetal development and live births, similar to the normal rats. The study provides a regenerative medicine therapeutics for uterine factor infertility. Abstract : Reconstructable uterus‐derived materials (RUMs) with different states and shapes can be designed and fabricated, achieving highly efficient live births in rats with severe uterine injury. The RUMs can effectively prevent intrauterine adhesion, and promote endometrial regeneration and muscle collagen reconstruction, as well as accelerate wound healing by constructing a physical barrier and secreting cytokines, allowing efficient uterus recovery and live births.