Changes in Body Weight and Knee Pain in Adults With Knee Osteoarthritis Three‐and‐a‐Half Years After Completing Diet and Exercise Interventions: Follow‐Up Study for a Single‐Blind, Single‐Center, Randomized Controlled Trial. Issue 4 (23rd February 2022) - Messier, Stephen P.
Abstract : Objective: To determine whether long‐term diet (D) and exercise (E) interventions, alone or in combination (D+E), have beneficial effects for older adults with knee osteoarthritis (OA) 3.5 years after the interventions end. Methods: This is a secondary analysis of a subset (n = 94) of the first 184 participants who had successfully completed the Intensive Diet and Exercise in Arthritis (IDEA) trial (n = 399) and who consented to follow‐up testing. Participants were older (age ≥55 years), overweight, and obese adults with radiographic and symptomatic knee OA in at least 1 knee who completed 1.5‐year D+E (n = 27), D (n = 35), or E (n = 32) interventions and returned for 5‐year follow‐up testing an average of 3.5 years later. Results: During the 3.5‐years following the interventions, weight regain in D+E and D was 5.9 kg (7%) and 3.1 kg (4%), respectively, with a 1‐kg (1%) weight loss in E. Compared to baseline, weight (D+E –3.7 kg [ P = 0.0007], D –5.8 kg [ P < 0.0001], E –2.9 kg [ P = 0.003]) and Western Ontario and McMaster Universities Osteoarthritis Index pain subscale scores (D+E –1.2 [ P = 0.03], D –1.5 [ P = 0.001], E –1.6 [ P = 0.0008]) were lower in each group at the 5‐year follow‐up. The effect of group assignment at the 5‐year follow‐up was significant for body weight, with D being less than E (–3.5 kg; P = 0.04). Conclusion: Older adults with knee OA who completed 1.5‐year D or D+E interventions experienced partial weight regain 3.5 years later; yet, relative to baseline, they preserved statistically significant changes in weight loss and reductions in knee pain.