Preclinical studies of chimeric antigen receptor-modified natural killer cells in cancer immunotherapy: a review. (4th March 2022)

• Record Type: Journal Article
• Authors: Hosseini, Mina; Habibi, Zahra; Hosseini, Narges; Abdoli, Sina; Rezaei, Nima
• Is Part Of: Expert opinion on biological therapy. Volume 22:Number 3(2022)
• Page Start: 349
• Page End: 366
• Publication Date: 2022-03-04
• Subjects: Adoptive transfer -- cancer -- chimeric antigen receptor -- immunotherapy -- natural killer cells; Gene therapy -- Periodicals; Protein drugs -- Periodicals; Peptide drugs -- Periodicals; Immunotherapy -- Periodicals; Drug delivery systems -- Periodicals; 615.5
• DOI: 10.1080/14712598.2021.1983539
• Languages: English
• ISSNs: 1471-2598

Abstract

ABSTRACT: Introduction: As one of the most efficacious methods of cancer immunotherapy, chimeric antigen receptor-modified immune cells have recently drawn enormous attention. After the great success achieved with CAR-T-cells in cancer treatment both in preclinical setting and in the clinic, other types of immune cells, including natural killer (NK)-cells and macrophages, have been evaluated for their anti-cancer effects along with their potential superiority against CAR-T-cells, especially in terms of safety. First introduced by Tran et al. almost 26 years ago, CAR-NK-cells are now being considered as efficient immunotherapeutic modalities in various types of cancers, not only in preclinical setting but also in numerous phase I and II clinical studies. Areas Covered: In this review, we aim to provide a comprehensive survey of the preclinical studies on CAR-NK-cells' development, with an evolutional approach on CAR structures and their associated signaling moieties. Current NK-cell sources and modes of gene transfer are also reviewed. Expert Opinion: CAR-NK-cells have appeared as safe and effective immunotherapeutic tools in preclinical settings; however, designing CAR structures with an eye on their specific biology, along with choosing the optimal cell source and gene transfer method require further investigation to support clinical studies.