The future of biological dosimetry in mass casualty radiation emergency response, personalized radiation risk estimation and space radiation protection. (4th March 2022)

• Record Type: Journal Article
• Authors: Ainsbury, Elizabeth A.; Moquet, Jayne; Sun, Mingzhu; Barnard, Stephen; Ellender, Michele; Lloyd, David
• Is Part Of: International journal of radiation biology. Volume 98:Number 3(2022)
• Page Start: 421
• Page End: 427
• Publication Date: 2022-03-04
• Subjects: Radiation -- biological dosimetry -- biomarkers of dose and risk -- space flight radiation; Radiation -- Physiological effect -- Periodicals; Radiobiology -- Periodicals; 571.45
• DOI: 10.1080/09553002.2021.1980629
• Languages: English
• ISSNs: 0955-3002

Abstract

Abstract: Purpose: The aim of this brief personal, high level review is to consider the state of the art for biological dosimetry for radiation routine and emergency response, and the potential future progress in this fascinating and active field. Four areas in which biomarkers may contribute to scientific advancement through improved dose and exposure characterization, as well as potential contributions to personalized risk estimation, are considered: emergency dosimetry, molecular epidemiology, personalized medical dosimetry, and space travel. Conclusion: Ionizing radiation biodosimetry is an exciting field which will continue to benefit from active networking and collaboration with the wider fields of radiation research and radiation emergency response to ensure effective, joined up approaches to triage; radiation epidemiology to assess long term, low dose, radiation risk; radiation protection of workers, optimization and justification of radiation for diagnosis or treatment of patients in clinical uses, and protection of individuals traveling to space. Graphical Abstract: UF0001 Well established and newer biodosimetric techniques show promise for a number of future dosimetry or wider research application. PCC: Premature chromosome condensation.