Chemical constituents and aldose reductase inhibitory activities of Betula alba bark and leaves. Issue 4 (16th February 2022)

• Record Type: Journal Article
• Authors: Iguchi, Tomoki; Kuroda, Minpei; Akiyama, Nanami; Hashimoto, Mariko; Mimaki, Yoshihiro
• Is Part Of: Natural product research. Volume 36:Issue 4(2022)
• Page Start: 1004
• Page End: 1008
• Publication Date: 2022-02-16
• Subjects: Betula alba -- Betulaceae -- bark -- leaf -- diarylheptanoid -- aldose reductase inhibitory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1839455
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Systematic phytochemical investigation of the bark and leaves of Betula alba was independently conducted. A new cyclic diarylheptanoid glucoside (1 ), five diarylheptanoids (2 –6 ), a phenylethanoid (7 ), a methyl salicylate glycoside (8 ), a dihydrobenzofuran glucoside (9 ), an arylbutanoid glycoside (10 ), two lignan glycosides (11 and 12 ), a flavanone glucoside (13 ), and a triterpene (14 ) were isolated from the bark of B. alba . On the other hand, two cyclic diarylheptanoids (15 and 16 ), five flavonoids (17 –21 ), a phenylpropanoid (22 ), a phenylbutanoid glucoside (23 ), and a monoterpene glucoside (24 ) were obtained from the leaves of B. alba . The structures of the isolated compounds (1 –24 ) were identified on the basis of one- and two-dimensional NMR spectroscopic data. Compounds 1 –24 were subsequently examined for aldose reductase (AR) inhibitory activity. Compounds 14 and 17 –20 moderately inhibited AR activity with IC50 values ranging from 6.6 to 34 µM. Graphical Abstract: