Resistance to kinase inhibition through shortened target engagement. (31st December 2022)
- Record Type:
- Journal Article
- Title:
- Resistance to kinase inhibition through shortened target engagement. (31st December 2022)
- Main Title:
- Resistance to kinase inhibition through shortened target engagement
- Authors:
- Rangwala, Aziz M.
Berger, Benedict-Tilman
Robers, Matthew B.
Knapp, Stefan
Seeliger, Markus A. - Abstract:
- ABSTRACT: Imatinib, a selective inhibitor of the breakpoint cluster region (BCR)-ABL kinase, is the poster child for targeted cancer therapeutics. However, its efficacy is limited by resistance mutations. Using a quantitative bioluminescence resonance energy transfer assay in living cells, we identified ABL kinase mutations that could cause imatinib resistance by altering drug residence time.
- Is Part Of:
- Molecular & cellular oncology. Volume 9:Number 1(2022)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 9:Number 1(2022)
- Issue Display:
- Volume 9, Issue 1 (2022)
- Year:
- 2022
- Volume:
- 9
- Issue:
- 1
- Issue Sort Value:
- 2022-0009-0001-0000
- Page Start:
- Page End:
- Publication Date:
- 2022-12-31
- Subjects:
- Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2022.2029999 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 21189.xml