Photoswitchable inhibitors of human β-glucocerebrosidase. Issue 8 (2nd February 2022)

• Record Type: Journal Article
• Authors: Davighi, Maria Giulia; Clemente, Francesca; Matassini, Camilla; Cardona, Francesca; Nielsen, Mogens Brøndsted; Goti, Andrea; Morrone, Amelia; Paoli, Paolo; Cacciarini, Martina
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 8(2022)
• Page Start: 1637
• Page End: 1641
• Publication Date: 2022-02-02
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02159a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Towards human GCase activity enhancement by means of light responsive inhibitors. Abstract : Light-switchable inhibitors of the enzyme β-glucocerebrosidase (GCase) have been developed by anchoring a specific azasugar to a dihydroazulene or an azobenzene responsive moiety. Their inhibitory effect towards human GCase, before and after irradiation are reported, and the effect on thermal denaturation of recombinant GCase and cytotoxicity were studied on selected candidates.