Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization. Issue 5 (19th January 2022)

• Record Type: Journal Article
• Authors: Yu, Xin; Zhang, Zhuo-Zhuo; Niu, Jun-Long; Shi, Bing-Feng
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 5(2022)
• Page Start: 1458
• Page End: 1484
• Publication Date: 2022-01-19
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01884a
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Recent advances in transition-metal-catalyzed enantioselective desymmetric C–H functionalization are summarized. Abstract : Transition-metal-catalyzed asymmetric C–H functionalization has gradually emerged as a powerful tool for the creation of structural and chiral complexity in an atom- and step-economical fashion. The nature of this strategy provides a variety of methodologies to overcome the limitation of enantioselective desymmetrization caused by the synthesis of preformed multifunctional symmetric substrates. This review aims to summarise recent advances in transition-metal-catalyzed enantioselective desymmetric C–H functionalization reactions via coordination-assisted metal insertion, covering the literature from 2008 to June 2021. The mechanistic pathway and the modes of stereocontrol are discussed where appropriate.