Physiological responses to pain in cancer patients: A systematic review. (April 2022)

• Record Type: Journal Article
• Authors: Moscato, Serena; Cortelli, Pietro; Chiari, Lorenzo
• Is Part Of: Computer methods and programs in biomedicine. Volume 217(2022)
• Publication Date: 2022-04
• Subjects: Pain assessment -- Cancer pain -- Physiological signals -- Autonomic signals -- Instrumented assessment; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2022.106682
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: This systematic review aims at summarizing the current knowledge regarding the association between physiological signals and pain experience in cancer patients. ECG and blood pressure are the most used signals. Literature shows a fair consistency in stating a positive correlation between pain experience and heart rate, LF/HF, and systolic blood pressure. The use of wearable devices, together with a big-data approach, can overcome limitations imposed by the current methods. Abstract: Background and objective: Pain is one of the most debilitating symptoms in persons with cancer. Still, its assessment is often neglected both by patients and healthcare professionals. There is increasing interest in conducting pain assessment and monitoring via physiological signals that promise to overcome the limitations of state-of-the-art pain assessment tools. This systematic review aims to evaluate existing experimental studies to identify the most promising methods and results for objectively quantifying cancer patients' pain experience. Methods: Four electronic databases (Pubmed, Compendex, Scopus, Web of Science) were systematically searched for articles published up to October 2020. Results: Fourteen studies (528 participants) were included in the review. The selected studies analyzed seven physiological signals. Blood pressure and ECG were the most used signals. Sixteen physiological parameters showed significant changes in association with pain. The studies were fairly consistent in stating that heart rate, the low-frequency to high-frequency component ratio (LF/HF), and systolic blood pressure positively correlate with the pain. Conclusions: Current evidence supports the hypothesis that physiological signals can help objectively quantify, at least in part, cancer patients' pain experience. While there is much more to be done to obtain a reliable pain assessment method, this review takes an essential first step by highlighting issues that should be taken into account in future research: use of a wearable device for pervasive recording in a real-world context, implementation of a big-data approach possibly supported by AI, including multiple stratification factors (e.g., cancer site and stage, source of pain, demographic and psychosocial data), and better-defined recording procedures. Improved methods and algorithms could then become valuable add-ons in taking charge of cancer patients.