Schistosomiasis in the People's Republic of China – down but not out. Issue 2 (3rd February 2022)
- Record Type:
- Journal Article
- Title:
- Schistosomiasis in the People's Republic of China – down but not out. Issue 2 (3rd February 2022)
- Main Title:
- Schistosomiasis in the People's Republic of China – down but not out
- Authors:
- Gordon, Catherine A.
Williams, Gail M.
Gray, Darren J.
Clements, Archie C. A.
Zhou, Xiao-Nong
Li, Yuesheng
Utzinger, Jürg
Kurscheid, Johanna
Forsyth, Simon
Addis Alene, Kefyalew
Zhou, Jie
Li, Zhaojun
Li, Guangpin
Lin, Dandan
Lou, Zhihong
Li, Shengming
Ge, Jun
Xu, Jing
Yu, Xinling
Hu, Fei
Xie, Shuying
Chen, Jie
Shi, Tao
Li, Chong
Zheng, Huajun
McManus, Donald P. - Abstract:
- Abstract: Abstract: Schistosomiasis has been subjected to extensive control efforts in the People's Republic of China (China) which aims to eliminate the disease by 2030. We describe baseline results of a longitudinal cohort study undertaken in the Dongting and Poyang lakes areas of central China designed to determine the prevalence of Schistosoma japonicum in humans, animals (goats and bovines) and Oncomelania snails utilizing molecular diagnostics procedures. Data from the Chinese National Schistosomiasis Control Programme (CNSCP) were compared with the molecular results obtained. Sixteen villages from Hunan and Jiangxi provinces were surveyed; animals were only found in Hunan. The prevalence of schistosomiasis in humans was 1.8% in Jiangxi and 8.0% in Hunan determined by real-time polymerase chain reaction (PCR), while 18.3% of animals were positive by digital droplet PCR. The CNSCP data indicated that all villages harboured S. japonicum -infected individuals, detected serologically by indirect haemagglutination assay (IHA), but very few, if any, of these were subsequently positive by Kato-Katz (KK). Based on the outcome of the IHA and KK results, the CNSCP incorporates targeted human praziquantel chemotherapy but this approach can miss some infections as evidenced by the results reported here. Sensitive molecular diagnostics can play a key role in the elimination of schistosomiasis in China and inform control measures allowing for a more systematic approach to treatment.
- Is Part Of:
- Parasitology. Volume 149:Issue 2(2022)
- Journal:
- Parasitology
- Issue:
- Volume 149:Issue 2(2022)
- Issue Display:
- Volume 149, Issue 2 (2022)
- Year:
- 2022
- Volume:
- 149
- Issue:
- 2
- Issue Sort Value:
- 2022-0149-0002-0000
- Page Start:
- 218
- Page End:
- 233
- Publication Date:
- 2022-02-03
- Subjects:
- Chinese National Schistosomiasis Control Programme -- digital droplet PCR (ddPCR) -- Dongting lake -- Hunan province -- Jiangxi province -- Kato-Katz -- LAMP -- People's Republic of China -- Poyang lake -- Real-time PCR (qPCR) -- Schistosoma japonicum -- Schistosomiasis
Parasitology -- Periodicals
Electronic journals
616.96 - Journal URLs:
- http://journals.cambridge.org/action/displayJournal?jid=PAR&bVolume=y ↗
http://journals.cambridge.org/action/displayJournal?jid=PAR ↗ - DOI:
- 10.1017/S0031182021001724 ↗
- Languages:
- English
- ISSNs:
- 0031-1820
- Deposit Type:
- Legaldeposit
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- British Library STI - ELD Digital store
- Ingest File:
- 21181.xml