Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features. (17th November 2021)

• Record Type: Journal Article
• Authors: Koreishi, Anjum F.; Zhou, Mei; Goldstein, Debra A.
• Is Part Of: Ocular immunology and inflammation. Volume 29:Number 7/8(2021)
• Page Start: 1312
• Page End: 1317
• Publication Date: 2021-11-17
• Subjects: TINU -- uveitis -- interstitial nephritis -- pediatric uveitis -- interstitial nephritis and uveitis -- tubulointerstitial nephritis and uveitis -- tubulointerstitial nephritis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2020.1736311
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To describe clinical manifestations of patients with tubulointerstitial nephritis and uveitis syndrome (TINU) with a focus on posterior segment findings. Methods : Retrospective chart review. Results : 17 patients were diagnosed with TINU. Ten (59%) were female. Average age at presentation was 19 years (range 7–49). Urine β2-microglobulin was elevated in all tested patients. Six patients (35%) had isolated anterior uveitis. Eleven (65%) had posterior segment findings. Three (18%) had multifocal choroidal lesions, seven (41%) had disc edema, four (24%) had macular edema, three (18%) had choroidal neovascular membranes, two (12%) had retinal vasculitis, one (6%) had disc neovascularization and vitreous hemorrhage, one (6%) had bilateral posterior scleritis. Eleven (65%) required systemic steroid therapy, seven (41%) required immunomodulatory therapy. Conclusions : TINU occurs in all age groups. Posterior segment manifestations are common. Most patients required systemic steroid therapy, with a significant number requiring long-term systemic immunomodulation. Careful fundus examination is required on all patients with TINU.