Combined Use of Mycobacterium tuberculosis–Specific CD4 and CD8 T-Cell Responses Is a Powerful Diagnostic Tool of Active Tuberculosis. (31st October 2014)

• Record Type: Journal Article
• Authors: Rozot, Virginie; Patrizia, Amelio; Vigano, Selena; Mazza-Stalder, Jesica; Idrizi, Elita; Day, Cheryl L.; Perreau, Matthieu; Lazor-Blanchet, Catherine; Ohmiti, Khalid; Goletti, Delia; Bart, Pierre-Alexandre; Hanekom, Willem; Scriba, Thomas J.; Nicod, Laurent; Pantaleo, Giuseppe; Harari, Alexandre
• Is Part Of: Clinical infectious diseases. Volume 60:Number 3(2014:Aug. 01)
• Page Start: 432
• Page End: 437
• Publication Date: 2014-10-31
• Subjects: diagnosis -- active tuberculosis disease -- latent Mtb infection -- functional profile -- CD8 T cells; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciu795
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection.