TBAI-catalyzed C–N bond formation through oxidative coupling of benzyl bromides with amines: a new avenue to the synthesis of amides. Issue 3 (1st February 2022)

• Record Type: Journal Article
• Authors: Kumar, Dhirendra; Maury, Suresh Kumar; Kumari, Savita; Kamal, Arsala; Singh, Himanshu Kumar; Singh, Sundaram; Srivastava, Vandana
• Is Part Of: Synthetic communications. Volume 52:Issue 3(2022)
• Page Start: 424
• Page End: 432
• Publication Date: 2022-02-01
• Subjects: Benzyl bromide -- oxidative coupling -- TBHP -- TBAI -- TEMPO; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2022.2029897
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A new green approach for the synthesis of amide through TBAI-catalyzed oxidative coupling of benzyl bromides with amine was developed in the presence of tert -butyl hydroperoxide (TBHP) as an oxidant. Various electron-donating and withdrawing groups containing benzyl bromides and various amines, were subjected to the reaction and transformed to the corresponding amide in good to excellent yields. Graphical Abstract: UF0001