Injectable and adhesive hydrogels for dealing with wounds. (3rd April 2022)

• Record Type: Journal Article
• Authors: Ghandforoushan, Parisa; Golafshan, Nasim; Babu Kadumudi, Firoz; Castilho, Miguel; Dolatshahi-Pirouz, Alireza; Orive, Gorka
• Is Part Of: Expert opinion on biological therapy. Volume 22:Number 4(2022)
• Page Start: 519
• Page End: 533
• Publication Date: 2022-04-03
• Subjects: Adhesive -- biomaterials -- injectable hydrogel -- medical applications -- tissue engineering -- wound healing; Gene therapy -- Periodicals; Protein drugs -- Periodicals; Peptide drugs -- Periodicals; Immunotherapy -- Periodicals; Drug delivery systems -- Periodicals; 615.5
• DOI: 10.1080/14712598.2022.2008353
• Languages: English
• ISSNs: 1471-2598

Abstract

ABSTRACT: Introduction: The development of wound dressing materials that combine healing properties, ability to self-repair the material damages, skin-friendly adhesive nature, and competent mechanical properties have surpassing functional importance in healthcare. Due to their specificity, hydrogels have been recognized as a new gateway in biological materials to treat dysfunctional tissues. The design and creation of injectable hydrogel-based scaffolds have extensively progressed in recent years to improve their therapeutic efficacy and to pave the way for their easy minimally invasive administration. Hence, injectable hydrogel biomaterials have been prepared to eventually translate into minimally invasive therapy and pose a lasting effect on regenerative medicine. Areas Covered: This review highlights the recent development of adhesive and injectable hydrogels that have applications in wound healing and wound dressing. Such hydrogel materials are not only expected to improve therapeutic outcomes but also to facilitate the easy surgical process in both wound healing and dressing. Expert Opinion: Wound healing seems to be an appealing approach for treating countless life-threatening disorders. With the average increase of life expectancy in human societies, an increase in demand for injectable skin replacements and drug delivery carriers for chronic wound healing is expected.