Tackling cancer cell dormancy: Insights from immune models, and transplantation. (January 2022)

• Record Type: Journal Article
• Authors: Corthay, Alexandre; Bakacs, Tibor; Thangavelu, Govindarajan; Anderson, Colin C.
• Is Part Of: Seminars in cancer biology. Volume 78(2022)
• Page Start: 5
• Page End: 16
• Publication Date: 2022-01
• Subjects: Cancer dormancy -- Immune tolerance -- T cell activation -- Coinhibitory -- Hyperthermia; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2021.02.002
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Disseminated non-dividing (dormant) cancer cells as well as those in equilibrium with the immune response remain the major challenge for successful treatment of cancer. The equilibrium between disseminated dormant cancer cells and the immune system is reminiscent of states that can occur during infection or allogeneic tissue and cell transplantation. We discuss here the major competing models of how the immune system achieves a self nonself discrimination (pathogen/danger patterns, quorum, and coinhibition/tuning models), and suggest that taking advantage of a combination of the proposed mechanisms in each model may lead to increased efficacy in tackling cancer cell dormancy.