Two new chemical constituents from the rhizomes of Actaea dahurica. Issue 7 (3rd April 2022)

• Record Type: Journal Article
• Authors: Ma, Sen-Ju; Li, Hai-Bo; Shao, Jun-Ran; Pang, Qian-Qian; Li, Ting; Yao, Xin-Sheng; Yu, Yang
• Is Part Of: Natural product research. Volume 36:Issue 7(2022)
• Page Start: 1789
• Page End: 1796
• Publication Date: 2022-04-03
• Subjects: Actaea dahurica -- phenylpropanoid allopyranoside -- indolinone alkaloid -- NO; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1817016
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new phenylpropanoid allopyranoside (1 ) and a new indolinone alkaloid (2 ) were isolated from the rhizomes of Actaea dahurica (syn. Cimicifuga dahurica ). The structures of those two compounds were deduced as cimicifugaside F (1 ) and 3 E, 11 E -(3-methyl-2-butenylidene acid)-2-indolinone-1- O - β -d -glucopyranoside (2 ) by detailed analysis of their MS, 1D and 2D NMR data and comparison with literatures. Additionally, the isolates were evaluated for their inhibitory effects on the production of NO by LPS-stimulated RAW 264.7 macrophages. Graphical Abstract: