Describing a modern therapeutic drug prepared by in situ decorated gold nanoparticles on starch-modified magnetic nanoparticles to treat the cutaneous wound: a preclinical trial study. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Li, Xiang; Feng, Hailun; Mei, Yonghong; Wu, Zeyong; Cai, Xiaofen; Xu, Zhiqiang; Hui, Jia; Wu, Zhiyuan
• Is Part Of: Journal of experimental nanoscience. Volume 17:Issue 1(2022)
• Page Start: 150
• Page End: 162
• Publication Date: 2022-12-31
• Subjects: Fe3O4/Starch-Au -- cutaneous wound healing -- antioxidant -- magnetic composite; Nanoscience -- Periodicals; Nanotechnology -- Periodicals; Nanomedicine -- Periodicals; Nanotechnology -- Periodicals; 620.5
• DOI: 10.1080/17458080.2022.2054994
• Languages: English
• ISSNs: 1745-8080

Abstract

Abstract: In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Au NP fabricated starch functionalized core-shell type nanomaterial (Fe3 O4 /Starch-Au nanocomposite). It was meticulously characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, VSM, XRD and ICP-OES. MTT assay was used on common normal cell line i.e. Human umbilical vein endothelial cells (HUVEC) to survey the cytotoxicity effects of Fe3 O4 /Starch-Au nanocomposite. In the part of cutaneous wound healing, use of Fe3 O4 /Starch-Au nanocomposite ointment, significantly ( p ≤ 0.01) raised the wound contracture, vessel, hydroxyl proline, hexuronic acid, fibrocyte, fibroblast, and fibrocytes/fibroblast rate and significantly ( p ≤ 0.01) decreased the wound area, total cells, neutrophil, and lymphocyte compared to other groups in rats. Finally, the results showed the useful cutaneous wound healing properties of Fe3 O4 /Starch-Au nanocomposite. Maybe significant cutaneous wound healing potentials of Fe3 O4 /Starch-Au nanocomposite are related to their antioxidant activities. For investigating the antioxidant activities of Fe3 O4 /Starch-Au nanocomposite, the DPPH test was used in the presence of butylated hydroxytoluene as the positive control. The Fe3 O4 /Starch-Au nanocomposite inhibited half of the DPPH molecules in the concentration of 156 µg/mL.