Quinolizidine alkaloids from the roots of Sophora flavescens. Issue 7 (3rd April 2022)

• Record Type: Journal Article
• Authors: Li, Jian-Chun; Zhang, Zhi-Jun; Liu, Dan; Jiang, Ming-Yan; Li, Rong-Tao; Li, Hong-Mei
• Is Part Of: Natural product research. Volume 36:Issue 7(2022)
• Page Start: 1781
• Page End: 1788
• Publication Date: 2022-04-03
• Subjects: Sophora flavescens Alt -- Sophora -- quinolizidine alkaloids -- anti-inflammation -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1817011
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1 ), were isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)- Δ 7 -dehydrosophoramine (10 ) and oxy- N -methylcytisine (12 ) were reported for the first time. In addition, (+)-sophoranol (4 ) exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 22.14 μM, while lupanine (17 ) was found to inhibit the growth of human glioma stem cells GSC-3# at 20 μg/mL. Graphical Abstract: