Clinical characteristics and in-hospital outcomes of COVID-19 patients with history of heart failure: a propensity score-matched study. Issue 1 (2nd January 2022)

• Record Type: Journal Article
• Authors: Murat, Bektas; Murat, Selda; Mert, Kadir Ugur; Bilgin, Muzaffer; Cavusoglu, Yuksel
• Is Part Of: Acta cardiologica. Volume 77:Issue 1(2022)
• Page Start: 37
• Page End: 44
• Publication Date: 2022-01-02
• Subjects: Heart failure -- coronavirus -- outcome -- COVID-19 -- hospitalization -- mortality; Cardiology -- Periodicals; Cardiology; Cardiologie -- Périodiques; Cardiology; Cardiologie; Periodicals; Periodicals; 616.12005
• DOI: 10.1080/00015385.2021.1945765
• Languages: English
• ISSNs: 0001-5385

Abstract

Abstract: Background: Data on the clinical course and outcomes of COVID-19 disease among patients with a history of heart failure (HF) are scarce. Therefore, the aim of this study was to assess the clinical characteristics, prognostic biomarkers and in-hospital outcomes of patients with a history of HF hospitalised with confirmed COVID-19. Methods: A total of 8321 consecutive patients hospitalised with suspected COVID-19 disease were screened. Furthermore, 3849 patients with laboratory-confirmed SARS-CoV-2 infection were included in the study. Two hundred and forty COVID-19 patients with a history of HF and 240 without HF paired with PSM were evaluated. Results: Mean age was 72.7 ± 9.90 years, and 64.6% were men. Oxygen saturation, systolic and diastolic blood pressure at admission were significantly lower and heart rate was significantly higher in patients with a history of HF compared to those without. Patients with HF, compared to those without, had significantly higher leukocyte count, D-dimer, CRP, procalcitonin, hsTnI, lactate and lower albumin and lymphocyte. Compared with patients without HF, those with previous HF had a longer length of stay at ICU (6.22 d vs. 3.71 d; p < 0.001), increased risk of mechanical ventilation (42.1% vs. 15.4%; p < 0.001), in-hospital death (39.2% vs. 15.4%; p < 0.001) and composite outcomes (52.9% vs. 17.1%; p < 0.001). Conclusion: History of HF is associated with a higher risk of mechanical ventilation, cardiogenic shock, mortality and longer ICU stay in patients hospitalised for COVID-19, therefore the diagnosis of HF alone is important for predicting clinical outcomes.