Three new diphenyl ethers from the lichen Parmotrema praesorediosum (Nyl.) Hale (Parmeliaceae). Issue 8 (18th April 2022)

• Record Type: Journal Article
• Authors: Huynh, Bui Linh Chi; Bui, Van Muoi; Nguyen, Kim Phi Phung; Pham, Nguyen Kim Tuyen; Nguyen, Tan Phat
• Is Part Of: Natural product research. Volume 36:Issue 8(2022)
• Page Start: 1934
• Page End: 1940
• Publication Date: 2022-04-18
• Subjects: Parmotrema praesorediosum -- Parmeliaceae -- praesorether -- diphenyl ether -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1837818
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new diphenyl ethers, named praesorethers E, F and G (1, 2 and 3 ), were isolated from the lichen Parmotrema praesorediosum . Their chemical structures were elucidated on the basis of extensively spectroscopic analysis including HR-ESI-MS and NMR as well as comparison with previously published data. These compounds were evaluated for the cytotoxicity against three human cancer cell lines (HeLa, NCI-H460 and MCF-7) using SRB assay. As results, 1 and 2 exhibited weak cytotoxic activity against three tested cancer cell lines with the inhibitive percentage of 64–79.9% at the concentration of 100 μg/mL while 3 was inactive. Graphical Abstract: