Iridium-catalyzed reductive etherification of α, β-unsaturated ketones and aldehydes with alcohols. Issue 13 (18th March 2022)

• Record Type: Journal Article
• Authors: Ouyang, Lu; Xia, Yanping; Miao, Rui; Liao, Jianhua; Luo, Renshi
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 13(2022)
• Page Start: 2621
• Page End: 2625
• Publication Date: 2022-03-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00122e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A new protocol for the synthesis of allyl ethers in superior yields through a one-pot sequential reductive etherification and alcohol condensation with α, β-unsaturated ketones and aldehydes. Abstract : An iridium complex-catalyzed reductive etherification of α, β-unsaturated ketones and aldehydes with primary alcohols is presented, affording allyl ethers in excellent yields. Deuterated and control experiments showed that this etherification transformation proceeded through a cascade transfer hydrogenation and alcohol condensation process. Moreover, the utility of this protocol is evidenced by the gram-scale performance.