MicroRNA-30c-2-3p targets STRIP2 to suppress malignant progression of gastric cancer cells. (1st February 2022)

• Record Type: Journal Article
• Authors: Wu, Junfei; Lu, Guochun; Zhou, Shengkun; Jin, Zier; Fang, Fu
• Is Part Of: Journal of biochemistry. Volume 171:Number 4(2022)
• Page Start: 451
• Page End: 457
• Publication Date: 2022-02-01
• Subjects: Biochemistry -- Periodicals; Biochemistry -- Periodicals; Electronic journals; 572.05
• DOI: 10.1093/jb/mvac006
• Languages: English
• ISSNs: 0021-924X

Abstract

Abstract: MicroRNA plays a crucial part in genesis and development of gastric cancer (GC). We uncovered that microRNA-30c-2-3p was down-regulated in GC tissue and cell lines. Suppression of microRNA-30c-2-3p promoted progression of GC cells in vitro . STRIP2 was confirmed as a target for microRNA-30c-2-3p. MicroRNA-30c-2-3p overexpression remarkably suppressed cell malignant behaviours, while reintroduction of STRIP2 partially restored the anticancer effect of microRNA-30c-2-3p. Taken together, these findings suggested that microRNA-30c-2-3p acted as a candidate tumour suppressor in GC by directly targeting STRIP2. Therefore, microRNA-30c-2-3p can be used as a towardly GC therapeutic target. Graphical Abstract: