Association Between the Severity of Periodontitis and Osteoarthritis in Middle‐Aged and Older Patients With Type 2 Diabetes Mellitus: A Nationwide Population‐Based Study. Issue 3 (19th January 2022)

• Record Type: Journal Article
• Authors: Kim, Hyoung‐Sik; Park, Hye‐Min; Kim, Haeyoung; Lee, Hye Sun; Son, Da‐Hye; Lee, Yong‐Jae
• Is Part Of: Arthritis care & research. Volume 74:Issue 3(2022)
• Page Start: 403
• Page End: 409
• Publication Date: 2022-01-19
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/acr.24484
• Languages: English
• ISSNs: 2151-464X

Abstract

Abstract : Objective: Periodontitis and osteoarthritis are major public health concerns that result in decreased quality of life among middle‐aged and older adults. We sought to examine whether the severity of periodontitis is related to osteoarthritis according to the presence of type 2 diabetes mellitus. Methods: This study included 3, 527 participants age ≥50 years from the Korean National Health and Nutrition Examination Survey. Periodontitis was assessed using the Community Periodontal Index; severe periodontitis was defined as periodontal tissue forming deep periodontal pockets ≥6‐mm depth. Osteoarthritis was defined as Kellgren/Lawrence grade ≥2 on radiographic images of the knee or hip area with joint pain. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for osteoarthritis according to the severity of periodontitis, stratified by type 2 diabetes mellitus, were calculated using multiple logistic regression analyses. Results: Participants with type 2 diabetes mellitus were more likely to have osteoarthritis as the severity of periodontitis increased (nonsevere periodontitis OR 1.23 [95% CI 0.67–2.32]; severe periodontitis OR 3.01 [95% CI 1.51–5.84]) after adjusting for age, sex, body mass index, smoking status, alcohol consumption, regular exercise, education level, household income, hypertension, and frequent tooth‐brushing. However, this positive association was not found in individuals without type 2 diabetes mellitus after adjusting for the same covariables. Conclusion: Severe periodontitis was positively and significantly associated with osteoarthritis in middle‐aged and older individuals with type 2 diabetes mellitus. Our findings suggest that the oral inflammation manifesting in periodontitis may be at least partly involved in the pathogenesis of osteoarthritis, particularly in patients with type 2 diabetes mellitus.