The ionic substituted octacalcium phosphate for biomedical applications: A new pathway to follow?. Issue 7 (1st April 2022)

• Record Type: Journal Article
• Authors: Ressler, Antonia; Ivanišević, Irena; Žužić, Andreja; Somers, Nicolas
• Is Part Of: Ceramics international. Volume 48:Issue 7(2022)
• Page Start: 8838
• Page End: 8851
• Publication Date: 2022-04-01
• Subjects: Bone regeneration -- Bone scaffolds -- Calcium phosphates -- Ionic substitution -- Octacalcium phosphate -- Osteogenesis; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2021.12.126
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Numerous studies have found that octacalcium phosphate possesses promising biological properties applicable to bone tissue regeneration. To further improve the osteogenic and regenerative properties of octacalcium phosphate, substitutions with Sr 2+, Zn 2+, Mg 2+, Fe 3+, Na +, F − and CO3 2− ions have been investigated in recent years. Despite that, hydroxyapatite is still considered the most promising calcium phosphate for bioactive bone grafts due to its biocompatibility, physicochemical similarity to biological apatite, osteoconductivity and strong bonding with the surrounding tissue. However, better biological properties of octacalcium phosphate in vivo as well as a larger volume of regenerated bone tissue, compared to hydroxyapatite, were confirmed by many studies. This review summarizes recent and relevant studies on cationic and anionic substitutions in the crystal lattice of octacalcium phosphate and its in vitro biological performance. It also discusses future challenges and prospects for the use of substituted octacalacium phosphate.