Prevalence of Multidrug-Resistant Klebsiella pneumoniae Clinical Isolates in Nepal. (22nd February 2022) - Odari, Ranjeeta
Abstract : Background . Multidrug-resistant Klebsiella pneumoniae (MDR-KP) are becoming increasingly common over the world. The focus of this research was to get a quantitative assessment of K . pneumoniae and their multidrug resistance (MDR) profile in Nepal. Methods . Three electronic databases: PubMed, Google Scholar, and Research4Life were used to search publications specifying K . pneumoniae infections and/or their MDR status from January 2015 to October 2021. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines was followed for the review, and R language 4.1.1 was used for analysis. Depending upon heterogeneity of data, we used random model for pooled data to examine the prevalence of the organism and the multidrug resistance. Results . Evaluation included 16 studies, and the pooled estimation of K . pneumoniae in total clinical samples was 3% (95% CI; 0.01–0.05). In the meta-analysis, 14 studies were combined for determining the prevalence of K . pneumoniae in total positive clinical isolates which was 16% (95% CI: 0.11–0.20), while from 12 research studies, MDR status in the pathogen was found to be 64% (95% CI, 0.53–0.74). Conclusion . The MDR status of K . pneumoniae as well as the prevalence of the bacteria in Nepal was analyzed which showed alarming situation about administration of antibiotics and indicated choosing and developing reliable antibiotic strategies.