Shen-Shuai-Ling Formulation Attenuates Renal Interstitial Fibrosis in Chronic Kidney Disease by Regulating SHH-Gli1 Signaling Pathway. (12th February 2022)

• Record Type: Journal Article
• Authors: Li, Ying; Tu, Haitao; Luo, Yan; Xiong, Weijian; Liu, Hong; Xiong, Yanying; Zhang, Qin; Li, Huihui; Gao, Xuan
• Other Names: Garg Ruchika Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2022(2022)
• Publication Date: 2022-02-12
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2022/3754985
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Background . Shen-Shuai-Ling Formulation (SSLF) has apparent effects on improving renal function, delaying the progression of chronic kidney disease (CKD). Methods . Fifty male SD rats were randomly divided into 5 groups: Sham group, Model group, SSLF group, CPN group, and C + S group. The morphological changes and the collagen fibers of the rat kidneys were observed by HE staining. The expression of α -SMA, Col I, SHH, Gli1, and snail1 was detected by Western blot and qPCR. Then, the cells were divided into the control group, SHH group, and SHH + SSLF serum group. Results . Compared with the Model group, the fibrosis in SSLF, CPN, and C + S groups was significantly alleviated. And, compared with those in the Model group, the expression of α -SMA, Col I, SHH, Gli1, Snail in SSLF, CPN, and C + S groups decreased remarkably. Conclusions . SSLF remarkably improves renal function and alleviates renal interstitial fibrosis in UUO rats.