CD38 Expression by Circulating and Skin-Infiltrating Lymphocytes from Sezary Syndrome Patients: A Flow Cytometry and Immunohistochemistry Study. (24th February 2022)

• Record Type: Journal Article
• Authors: Quaglino, Pietro; Novelli, Mauro; Fava, Paolo; Ortolan, Erika; Astrua, Chiara; Tonella, Luca; Tomasini, Carlo Francesco; Senetta, Rebecca; Ribero, Simone; Ponti, Renata; Fierro, Maria Teresa; Funaro, Ada
• Other Names: Nicolazzo Chiara Academic Editor.
• Is Part Of: Disease markers. Volume 2022(2022)
• Publication Date: 2022-02-24
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2022/3424413
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Background . Reports on the expression of CD38 in Sézary syndrome (SS), erythrodermic primary cutaneous T cell lymphoma with leukemic involvement, are limited. The aim of the present study is the analysis of the expression of CD38 by skin-infiltrating mononuclear cells and circulating T lymphocytes in a cohort of SS patients. Methods . SS patients diagnosed since 1985 in our clinic were retrospectively analyzed for CD38 expression in biopsy and blood samples by immunohistochemistry and flow cytometry, respectively. Results . SS patients show a predominant CD38-negative phenotype on both skin and blood. A subgroup of patients was found expressing CD38 (12 cases) in either the skin (>25% cell infiltrate) or blood (CD4+CD38+ >50%), among whom 4 in the blood, 7 in the skin, and 1 in both blood and skin. Conclusion . The implications of these observations may be twofold: the relevance in basic science is related to a potential role in immune defense regulation, whilst in perspective CD38 may become a target for antibody therapy, considering the availability of different anti-CD38 monoclonal antibodies.