Two new metabolites from Portulaca oleracea and their anti-inflammatory activities. (April 2022)

• Record Type: Journal Article
• Authors: Tian, Jiayin; Ying, Ziyue; Lan, Xiujuan; Li, Yongjie; Leng, Aijing; Ying, Xixiang
• Is Part Of: Phytochemistry letters. Volume 48(2022)
• Page Start: 114
• Page End: 119
• Publication Date: 2022-04
• Subjects: IR infrared -- UV ultraviolet -- NMR nuclear magnetic resonance -- UHPLC-ESI-QTOF/MS ultrahigh-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry -- DMEM Dulbecco's modified Eagle's medium -- IL-1β interleukin-1β -- LPS lipopolysaccharide -- Dex dexamethasone -- DMSO dimethylsulfoxide -- PBS phosphate-buffered saline -- FBS fetal bovine serum -- AD Alzheimer's disease; Portulaca oleracea L. -- Metabolites -- Anti-inflammatory activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.02.007
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Two new metabolites, identified as 6-phenylbenzofuran-4-ol, named olerabenzofuran (1 ), and 2-(furan-2-yl)− 6-hydroxy-1 H-inden-1-one, named oleraindenone (2 ), together with eight furan compounds obtained for the first time, (+)-pinoresinol (3 ), (-)-syringaresinol (4 ), (+)-diasyringaresinol (5 ), (+)-episyringaresinol (6 ), (2 S )− 1-[2-(furan-2-yl)− 2-oxoethyl]− 5-oxopyrrolidine-2-carboxylic acid (7 ), methyl (2 S )− 1[2-(furan-2-yl)− 2-oxoethyl]− 5-oxopyrrolidine-2-carboxylate (8 ), drynaran (9 ), and 2-furoic acid (10 ), were isolated from Portulaca oleracea L., and spectroscopic methods, including 1D and 2 D NMR and UHPLC-ESI-QTOF/MS spectrometry techniques, were employed to determine their structures. It was suggested that both olerabenzofuran (1 ) and oleraindenone (2 ) could significantly inhibit inflammatory factor interleukin-1 β (IL-1 β ) in RAW 264.7 cells induced by LPS. Graphical Abstract: ga1 Highlights: Two new metabolites were isolated from Portulaca oleracea L. The metabolites exhibited significant anti-inflammatory bioactivities. Our findings may provide a novel therapeutic potential for Alzheimer's disease.