Human exposure to F-53B in China and the evaluation of its potential toxicity: An overview. (March 2022)

• Record Type: Journal Article
• Authors: He, Yanxia; Lv, Di; Li, Chuanhai; Liu, Xiuqin; Liu, Wendong; Han, Wenchao
• Is Part Of: Environment international. Volume 161(2022)
• Publication Date: 2022-03
• Subjects: F-53B -- Human exposure -- Toxicity -- China; PFASs per-and polyfluoroalkyl substances -- PFOS perfluorooctane sulfonate -- F-53B chlorinated polyfluoroalkyl ether sulfonic acids -- HSA human serum albumin -- CSF cerebrospinal fluid -- LOD the limit of detection -- DR detection rate -- TTE transplacental transfer efficiency -- TC total cholesterol -- T testosterone -- E2 estradiol -- LH luteinizing hormone -- MCP-1 monocyte chemoattractant protein-1 -- LC50 median lethal concentration -- TG triglyceride -- LDL low-density lipoprotein -- T4 thyroxine -- F0 adult zebrafish -- F1 F0 offspring -- T3 3, 5, 3'-triiodothyronine -- TH thyroid hormone -- TTR transthyretin -- F2 F1 offspring -- FSH follicle stimulating hormone -- mESCs mouse embryonic stem cells -- MDA malondialdehyde -- GSH glutathione -- CAT catalase -- SOD superoxide dismutase -- CuZn-SOD CuZn-superoxide dismutase -- GSH-Px glutathione peroxidase; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2022.107108
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: F-53B has been ubiquitously detected in humans. F-53B can induce lipid metabolism, endocrine disorders and foetal growth in humans. The biological toxicity of F-53B and its potential mechanisms have been reviewed. Abstract: Chlorinated polyfluoroalkyl ether sulfonic acid (Cl-PFESAs, trade name F-53B), an alternative to perfluorooctane sulfonate (PFOS), has been widely used as a mist suppressant in the Chinese electroplating industry since the 1970 s. Due to greater restrictions on PFOS globally in recent years, the production and use of F-53B correspondingly increased, consequently causing more emissions into the environment. In China, an increasing number of studies report frequent detection and broad exposure to F-53B in the natural environment, various wildlife and the human body. In human blood, the detection rate of F-53B is almost 80%, accounting for 8.69 to 28% of ∑per- and polyfluoroalkyl substances (PFASs). F-53B is the most biopersistent PFAS in humans to date, with a half-life of 15.3 years. In addition, F-53B displays protein binding affinity and high human placental permeability. Recently, some epidemiological studies have reported the health risks associated with F-53B in humans, including abnormal serum lipid metabolism, vascular dysfunction, endocrine disorders and even adverse birth outcomes. Various in vivo and in vitro studies have demonstrated the toxicity of F-53B, such as hepatotoxicity, interference effects on the endocrine system, as well as reproductive and developmental toxicity. Our aims are to review studies on human F-53B exposure levels, trends and associated health effects; evaluate the potential toxicity; and predict directions for future research.