Copper‐Catalyzed Decarbonylative Cyclization of Isatins and Trifluoroacetimidohydrazides for the Synthesis of 2‐(5‐Trifluoromethyl‐1, 2, 4‐triazol‐3‐yl)anilines. Issue 5 (28th January 2022)

• Record Type: Journal Article
• Authors: Zhang, Yu; Yang, Zuguang; Chen, Zhengkai; Liu, Leifang; Wu, Xiao‐Feng
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 5(2022)
• Page Start: 1044
• Page End: 1049
• Publication Date: 2022-01-28
• Subjects: trifluoroacetimidohydrazides -- isatins -- decarbonylative cyclization reaction -- 5-trifluoromethyl-1, 2, 4-triazoles -- N-heterocycles; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202101397
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A copper‐catalyzed intramolecular decarbonylative cyclization reaction of isatins and trifluoroacetimidohydrazides for the synthesis of 2‐(5‐trifluoromethyl‐1, 2, 4‐triazol‐3‐yl)aniline derivatives has been developed. This transformation proceeds through a cascade condensation, hydrolysis, decarboxylation, and intramolecular C−N bond formation sequence. The obtained 1, 2, 4‐triazole products bearing a free amino group can be readily converted into other useful compounds. Abstract :