Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19. (April 2022)

• Record Type: Journal Article
• Authors: Keene, Adam B.; Admon, Andrew J.; Brenner, Samantha K.; Gupta, Shruti; Lazarous, Deepa; Leaf, David E.; Gershengorn, Hayley B.
• Other Names: Walther Carl P. non-byline-author.; Anumudu Samaya J. non-byline-author.; Arunthamakun Justin non-byline-author.; Kopecky Kathleen F. non-byline-author.; Milligan Gregory P. non-byline-author.; McCullough Peter A. non-byline-author.; Nguyen Thuy-Duyen non-byline-author.; Shaefi Shahzad non-byline-author.; O'Gara Brian P. non-byline-author.; Krajewski Megan L. non-byline-author.; Baskin Sean M. non-byline-author.; Shankar Sidharth non-byline-author.; Valencia Juan D. non-byline-author.; Pannu Ameeka non-byline-author.; Hayes Margaret M. non-byline-author.; Grandin E. Wilson non-byline-author.; Waikar Sushrut S. non-byline-author.; Kibbelaar Zoe A. non-byline-author.; Athavale Ambarish M. non-byline-author.; Hart Peter non-byline-author.; Upadhyay Shristi non-byline-author.; Vohra Ishaan non-byline-author.; Oyintayo Ajiboye non-byline-author.; Green Adam non-byline-author.; Rachoin Jean-Sebastien non-byline-author.; Schorr Christa A. non-byline-author.; Shea Lisa non-byline-author.; Edmonston Daniel L. non-byline-author.; Mosher Christopher L. non-byline-author.; Shehata Alexandre M. non-byline-author.; Cohen Zaza non-byline-author.; Allusson Valerie non-byline-author.; Bambrick-Santoyo Gabriela non-byline-author.; ul aain Bhatti Noor non-byline-author.; Mehta Bijal non-byline-author.; Williams Aquino non-byline-author.; Brenner Samantha K. non-byline-author.; Walters Patricia non-byline-author.; Go Ronaldo C. non-byline-author.; Rose Keith M. non-byline-author.; Hernán; Miguel A. non-byline-author.; Lisk Rebecca non-byline-author.; Chan Lili non-byline-author.; Mathews Kusum S. non-byline-author.; Coca Steven G. non-byline-author.; Altman Deena R. non-byline-author.; Saha Aparna non-byline-author.; Soh Howard non-byline-author.; Wen Huei Hsun non-byline-author.; Bose Sonali non-byline-author.; Leven Emily A. non-byline-author.; Wang Jing G. non-byline-author.; Mosoyan Gohar non-byline-author.; Nadkarni Girish N. non-byline-author.; Pattharanitima Pattharawin non-byline-author.; Gallagher Emily J. non-byline-author.; Friedman Allon N. non-byline-author.; Guirguis John non-byline-author.; Kapoor Rajat non-byline-author.; Meshberger Christopher non-byline-author.; Kelly Katherine J. non-byline-author.; Parikh Chirag R. non-byline-author.; Garibaldi Brian T. non-byline-author.; Corona-Villalobos Celia P. non-byline-author.; Wen Yumeng non-byline-author.; Menez Steven non-byline-author.; Malik Rubab F. non-byline-author.; Elena Cervantes Carmen non-byline-author.; Gautam Samir C. non-byline-author.; Mallappallil Mary C. non-byline-author.; Ouyang Jie non-byline-author.; John Sabu non-byline-author.; Yap Ernie non-byline-author.; Melaku Yohannes non-byline-author.; Mohamed Ibrahim non-byline-author.; Bajracharya Siddhartha non-byline-author.; Puri Isha non-byline-author.; Thaxton Mariah non-byline-author.; Bhattacharya Jyotsna non-byline-author.; Wagner John non-byline-author.; Boudourakis Leon non-byline-author.; Nguyen H. Bryant non-byline-author.; Ahoubim Afshin non-byline-author.; Thomas Leslie F. non-byline-author.; Sirganagari Dheeraj Reddy non-byline-author.; Guru Pramod K. non-byline-author.; Kashani Kianoush non-byline-author.; Tehranian Shahrzad non-byline-author.; Zhou Yan non-byline-author.; Bergl Paul A. non-byline-author.; Rodriguez Jesus non-byline-author.; Shah Jatan A. non-byline-author.; Gupta Mrigank S. non-byline-author.; Kumar Princy N. non-byline-author.; Lazarous Deepa G. non-byline-author.; Kassaye Seble G. non-byline-author.; Melamed Michal L. non-byline-author.; Johns Tanya S. non-byline-author.; Mocerino Ryan non-byline-author.; Prudhvi Kalyan non-byline-author.; Zhu Denzel non-byline-author.; Levy Rebecca V. non-byline-author.; Azzi Yorg non-byline-author.; Fisher Molly non-byline-author.; Yunes Milagros non-byline-author.; Sedaliu Kaltrina non-byline-author.; Golestaneh Ladan non-byline-author.; Brogan Maureen non-byline-author.; Kumar Neelja non-byline-author.; Chang Michael non-byline-author.; Thakkar Jyotsana non-byline-author.; Raichoudhury Ritesh non-byline-author.; Athreya Akshay non-byline-author.; Farag Mohamed non-byline-author.; Schenck Edward J. non-byline-author.; Jung Cho Soo non-byline-author.; Plataki Maria non-byline-author.; Alvarez-Mulett Sergio L. non-byline-author.; Gomez-Escobar Luis G. non-byline-author.; Pan Di non-byline-author.; Lee Stefi non-byline-author.; Krishnan Jamuna non-byline-author.; Whalen William non-byline-author.; Charytan David non-byline-author.; Macina Ashley non-byline-author.; Chaudhry Sobaata non-byline-author.; Wu Benjamin non-byline-author.; Modersitzki Frank non-byline-author.; Srivastava Anand non-byline-author.; Leidner Alexander S. non-byline-author.; Martinez Carlos non-byline-author.; Kruser Jacqueline M. non-byline-author.; Wunderink Richard G. non-byline-author.; Hodakowski Alexander J. non-byline-author.; Velez Juan Carlos Q. non-byline-author.; Price-Haywood Eboni G. non-byline-author.; Matute-Trochez Luis A. non-byline-author.; Hasty Anna E. non-byline-author.; Mohamed Muner MB. non-byline-author.; Avasare Rupali S. non-byline-author.; Zonies David non-byline-author.; Leaf David E. non-byline-author.; Gupta Shruti non-byline-author.; Sise Meghan E. non-byline-author.; Newman Erik T. non-byline-author.; Abu Omar Samah non-byline-author.; Pokharel Kapil K. non-byline-author.; Sharma Shreyak non-byline-author.; Singh Harkarandeep non-byline-author.; Correa Simon non-byline-author.; Shaukat Tanveer non-byline-author.; Kamal Omer non-byline-author.; Wang Wei non-byline-author.; Yang Heather non-byline-author.; Boateng Jeffery O. non-byline-author.; Lee Meghan non-byline-author.; Strohbehn Ian A. non-byline-author.; Li Jiahua non-byline-author.; Mueller Ariel L. non-byline-author.; Redfern Roberta E. non-byline-author.; Cairl Nicholas S. non-byline-author.; Naimy Gabriel non-byline-author.; Abu-Saif Abeer non-byline-author.; Hall Danyell non-byline-author.; Bickley Laura non-byline-author.; Rowan Chris non-byline-author.; Madhani-Lovely Farah non-byline-author.; Peev Vasil non-byline-author.; Reiser Jochen non-byline-author.; Byun John J. non-byline-author.; Vissing Andrew non-byline-author.; Kapania Esha M. non-byline-author.; Post Zoe non-byline-author.; Patel Nilam P. non-byline-author.; Hermes Joy-Marie non-byline-author.; Sutherland Anne K. non-byline-author.; Patrawalla Amee non-byline-author.; Finkel Diana G. non-byline-author.; Danek Barbara A. non-byline-author.; Arikapudi Sowminya non-byline-author.; Paer Jeffrey M. non-byline-author.; Cangialosi Peter non-byline-author.; Liotta Mark non-byline-author.; Radbel Jared non-byline-author.; Puri Sonika non-byline-author.; Sunderram Jag non-byline-author.; Scharf Matthew T. non-byline-author.; Ahmed Ayesha non-byline-author.; Berim Ilya non-byline-author.; Vatson Jayanth S. non-byline-author.; Anand Shuchi non-byline-author.; Levitt Joseph E. non-byline-author.; Garcia Pablo non-byline-author.; Boyle Suzanne M. non-byline-author.; Song Rui non-byline-author.; Arif Ali non-byline-author.; Zhang Jingjing non-byline-author.; Woo Sang Hoon non-byline-author.; Deng Xiaoying non-byline-author.; Katz-Greenberg Goni non-byline-author.; Senter Katharine non-byline-author.; Sharshir Moh'd A. non-byline-author.; Rusnak Vadym V. non-byline-author.; Imran Ali Muhammad non-byline-author.; Peters Terri non-byline-author.; Hughes Kathy non-byline-author.; Bansal Anip non-byline-author.; Podoll Amber S. non-byline-author.; Chonchol Michel non-byline-author.; Sharma Sunita non-byline-author.; Burnham Ellen L. non-byline-author.; Rashidi Arash non-byline-author.; Hejal Rana non-byline-author.; Judd Eric non-byline-author.; Latta Laura non-byline-author.; Tolwani Ashita non-byline-author.; Albertson Timothy E. non-byline-author.; Adams Jason Y. non-byline-author.; Chang Steven Y. non-byline-author.; Beutler Rebecca M. non-byline-author.; Schulze Carl E. non-byline-author.; Macedo Etienne non-byline-author.; Rhee Harin non-byline-author.; Liu Kathleen D. non-byline-author.; Jotwani Vasantha K. non-byline-author.; Koyner Jay L. non-byline-author.; Kunczt Alissa non-byline-author.; Shah Chintan V. non-byline-author.; Jaikaransingh Vishal non-byline-author.; Toth-Manikowski Stephanie M. non-byline-author.; Joo Min J. non-byline-author.; Lash James P. non-byline-author.; Neyra Javier A. non-byline-author.; Chaaban Nourhan non-byline-author.; Elias Madona non-byline-author.; Ahmad Yahya non-byline-author.; Dy Rajany non-byline-author.; Iardino Alfredo non-byline-author.; Au Elizabeth H. non-byline-author.; Sharma Jill H. non-byline-author.; Anne Sosa Marie non-byline-author.; Taldone Sabrina non-byline-author.; Contreras Gabriel non-byline-author.; De La Zerda David non-byline-author.; Fornoni Alessia non-byline-author.; Gershengorn Hayley B. non-byline-author.; Hayek Salim S. non-byline-author.; Blakely Pennelope non-byline-author.; Berlin Hanna non-byline-author.; Azam Tariq U. non-byline-author.; Shadid Husam non-byline-author.; Pan Michael non-byline-author.; O" Hayer Patrick non-byline-author.; Meloche Chelsea non-byline-author.; Feroze Rafey non-byline-author.; Padalia Kishan J. non-byline-author.; Bitar Abbas non-byline-author.; Leya Jeff non-byline-author.; Donnelly John P. non-byline-author.; Admon Andrew J. non-byline-author.; Flythe Jennifer E. non-byline-author.; Tugman Matthew J. non-byline-author.; Chang Emily H. non-byline-author.; Brown Brent R. non-byline-author.; Leonberg-Yoo Amanda K. non-byline-author.; Spiardi Ryan C. non-byline-author.; Miano Todd A. non-byline-author.; Roche Meaghan S. non-byline-author.; Vasquez Charles R. non-byline-author.; Bansal Amar D. non-byline-author.; Ernecoff Natalie C. non-byline-author.; Kapoor Sanjana non-byline-author.; Verma Siddharth non-byline-author.; Chen Huiwen non-byline-author.; Kovesdy Csaba P. non-byline-author.; Molnar Miklos Z. non-byline-author.; Azhar Ambreen non-byline-author.; Susan Hedayati S. non-byline-author.; Nadamuni Mridula V. non-byline-author.; Shastri Shani non-byline-author.; Willett Duwayne L. non-byline-author.; Short Samuel A.P. non-byline-author.; Renaghan Amanda D. non-byline-author.; Enfield Kyle B. non-byline-author.; Bhatraju Pavan K. non-byline-author.; Bilal Malik A. non-byline-author.; Semler Matthew W. non-byline-author.; Vijayan Anitha non-byline-author.; Mariyam Joy Christina non-byline-author.; Li Tingting non-byline-author.; Goldberg Seth non-byline-author.; Kao Patricia F. non-byline-author.; Schumaker Greg L. non-byline-author.; Goyal Nitender non-byline-author.; Faugno Anthony J. non-byline-author.; Schumaker Greg L. non-byline-author.; Hsu Caroline M. non-byline-author.; Tariq Asma non-byline-author.; Meyer Leah non-byline-author.; Kshirsagar Ravi K. non-byline-author.; Jose Aju non-byline-author.; Weiner Daniel E. non-byline-author.; Christov Marta non-byline-author.; Chugh Savneek non-byline-author.; Griffiths Jennifer non-byline-author.; Gupta Sanjeev non-byline-author.; Kapoor Aromma non-byline-author.; Chugh Savneek non-byline-author.; Wilson Perry non-byline-author.; Arora Tanima non-byline-author.; Ugwuowo Ugochukwu non-byline-author.;
• Is Part Of: Journal of intensive care medicine. Volume 37:Number 4(2022)
• Page Start: 500
• Page End: 509
• Publication Date: 2022-04
• Subjects: COVID-19 -- intensive care unit -- mortality -- surge -- occupancy; Critical care medicine -- Periodicals; Critical Care -- Periodicals; Soins intensifs -- Périodiques; Soins intensifs; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.02805
• DOI: 10.1177/08850666211067509
• Languages: English
• ISSNs: 0885-0666

Abstract

Objective: To determine whether surge conditions were associated with increased mortality. Design: Multicenter cohort study. Setting: U.S. ICUs participating in STOP-COVID. Patients: Consecutive adults with COVID-19 admitted to participating ICUs between March 4 and July 1, 2020. Interventions: None Measurements and Main Results: The main outcome was 28-day in-hospital mortality. To assess the association between admission to an ICU during a surge period and mortality, we used two different strategies: (1) an inverse probability weighted difference-in-differences model limited to appropriately matched surge and non-surge patients and (2) a meta-regression of 50 multivariable difference-in-differences models (each based on sets of randomly matched surge- and non-surge hospitals). In the first analysis, we considered a single surge period for the cohort (March 23 – May 6). In the second, each surge hospital had its own surge period (which was compared to the same time periods in matched non-surge hospitals). Our cohort consisted of 4342 ICU patients (average age 60.8 [sd 14.8], 63.5% men) in 53 U.S. hospitals. Of these, 13 hospitals encountered surge conditions. In analysis 1, the increase in mortality seen during surge was not statistically significant (odds ratio [95% CI]: 1.30 [0.47-3.58], p = .6). In analysis 2, surge was associated with an increased odds of death (odds ratio 1.39 [95% CI, 1.34-1.43], p < .001). Conclusions: Admission to an ICU with COVID-19 in a hospital that is experiencing surge conditions may be associated with an increased odds of death. Given the high incidence of COVID-19, such increases would translate into substantial excess mortality.