Muricazine, a new hydrazine derivative from Ranunculus muricatus L. with antioxidant, lipoxygenase and urease inhibitory activities. Issue 4 (16th February 2022)

• Record Type: Journal Article
• Authors: Raziq, Naila; Saeed, Muhammad; Ali, Muhammad Shaiq; Shahid, Muhammad; Lateef, Mehreen; Zafar, Salman
• Is Part Of: Natural product research. Volume 36:Issue 4(2022)
• Page Start: 961
• Page End: 966
• Publication Date: 2022-02-16
• Subjects: Muricazine -- Ranunculaceae -- antioxidant -- lipoxygenase inhibition -- urease inhibition; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1855169
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Ranunculus muricatus L., an important member of family Ranunculaceae upon submission to phytochemical studies, led to the isolation of a novel natural hydrazine derivative, muricazine (1 ). Chemical structure of the compound was established with the aid of advanced spectroscopic techniques. It was evaluated for in vitro antioxidant, lipoxygenase, and urease (jack-bean) inhibitory activities. Results suggested that compound 1 could scavenge the DPPH free radical (42.1 ± 0.12 μ M) to a great extent as compared to the standard (40.6 ± 0.91 μ M). However, it showed moderate inhibitory potential against lipoxygenase (65.2 ± 0.45 μ M) and urease (54.8 ± 0.23 μ M) enzymes. Graphical Abstract: