Fabrication of Biobased Nanocomposites by Chemical Intervention of Nano‐Hydroxyapatite in Aloe Vera Gel‐Guava Seed Matrix for Bone Tissue Engineering. Issue 6 (8th February 2022)

• Record Type: Journal Article
• Authors: Mirza, Sumbul; Jolly, Reshma; Zia, Iram; Umar, Mohd S.; Owais, Mohammad; Shakir, Mohammad
• Is Part Of: ChemistrySelect. Volume 7:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-08
• Subjects: Bone tissue engineering -- materials science -- nanostructure -- natural products; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202103051
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The sharp increase in the bone defect related cases have derived an urgent search for novel bone implants which possess identical mechanical aspect as natural bone, along with commendable osteogenic property. Thus, to accomplish these requirements, in the present study, nano‐hydroxyapatite (nHA) reinforced guava seed (GS) – aloe vera (AV) gel nanocomposites were synthesized via a co precipitation approach with an attempt to induce bone mimicking activity. Three ternary systems were fabricated varying the concentration of different components as – nHA/GS/AV in the ratio of 70/20/10 (HGAV1), 70/15/15 (HGAV2) and 70/10/20 (HGAV3). All of the nanocomposites revealed a high cellular viability confirmed from fluorescence microscopy, increased osteogenic activity, phenomenal antibacterial activity, lower haemolysis, and high protein adsorption. These findings suggested that the use of natural products GS and AV gel for fabrication of nanocomposites gave them profound bioactivity and biocompatibility and exhibited a great potential in dental and orthopaedic applications. Abstract : The aim of current study was to assess the biocompatibility of aloe vera gel/ guava seed/nano hydroxyapatite nanocomposite which can further form the basis of their application as a favourable platform for bone regeneration. The results suggested that the designed nanocomposite scaffolds possessed exceptional cytocompatibility, good osteoinductivity, along with a suitable host tissue response, which could make them an appropriate candidate for bone tissue engineering.