In Vivo Sol–Gel Reaction of Tantalum Alkoxide for Endovascular Embolization. Issue 4 (23rd November 2021)

• Record Type: Journal Article
• Authors: Ko, Giho; Choi, Jin Woo; Shin, Kwangsoo; Kim, Young Geon; Kang, Taegyu; Kim, Dokyoon; Lee, Nohyun; Kim, Hyo‐Cheol; Hyeon, Taeghwan
• Other Names: Hudalla Gregory A. guestEditor.
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-23
• Subjects: cancer -- embolization -- HCC -- liquid embolic agents -- minimally invasive procedures -- sol–gel reaction; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202101908
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Liquid embolic agents are considered the most promising for various embolization procedures because they enable deep penetration. For realizing effective procedures, the delivery of liquid embolic agents should be guided under X‐ray imaging systems and the solidification time should be optimized for the specific indication. The biocompatibility of embolic agents is also crucial because they remain in the vessel after embolization. In this study, new biocompatible embolic agents based on tantalum ethoxide is synthesized. Tantalum alkoxide liquid embolics (TALE) possess the radiopacity for fluoroscopy and can control the penetration depth by modifying the sol–gel kinetics. Furthermore, TALE can serve as drug carriers for synergistic treatment. Using these excellent characteristics, it is demonstrated that TALE agents can be used in various situations including the transarterial chemoembolization of hepatocellular carcinoma and embolotherapy of massive bleeding from the femoral artery. Abstract : Tantalum‐based sol–gel precursors are presented as a novel material for permanent embolization by in vivo sol–gel reaction. New liquid embolic agent offers controllability on penetration depth, biocompatibility, and ability to drug delivery. Using these outstanding performances over clinically available counterparts, hepatocellular carcinoma in rats were successfully eliminated and life‐threatening hemorrhage is prevented.