Comparative Study of Nitro‐ and Azide‐Functionalized ZnII‐Based Coordination Polymers (CPs) as Fluorescent Turn‐On Probes for Rapid and Selective Detection of H2S in Living Cells. Issue 9 (19th January 2022)

• Record Type: Journal Article
• Authors: Saha, Subhajit; Roy, Pritam Kumar; Maity, Kartik; Mandal, Mahitosh; Biradha, Kumar
• Is Part Of: Chemistry. Volume 28:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-19
• Subjects: cell imaging -- coordination polymers -- essential elements -- fluorescence -- H2S sensors; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202103830
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Selective detection of H2 S in the cellular systems using fluorescent CPs/MOFs is of great scientific interest due to their outstanding aqueous stability, biocompatibility and real‐time detection ability. Fabrication of such materials using complete biologically essential elements and applying them as an efficient biosensor is still quite challenging. In this context, two newly synthesized CPs containing biologically essential metal ion (Zn) and nitro/azido functional groups into the framework to sense extracellular and intracellular H2 S by reducing into respective amines are presented. The CP‐1 containing the azide group acted as an efficient fluorescent turn‐on probe with the lowest detection limit (7.2 μM) and shortest response time (30 s) among the Zn‐based probes reported till date. Moreover, CP‐1 exhibited green luminescence in live cells after imaging a very low concentration of H2 S, whereas the nitro analogue CP‐2 could not detect the target analyte due to its framework disruption. Abstract : Based on the reduction approach, newly synthesized coordination polymers (CPs) containing biologically essential metal ion (Zn) was shown to exhibit an excellent ability for the detection of extracellular and intracellular H2 S. The CP‐1, containing azido functunal group acted as an efficient fluorencent turn‐on probe with lowest detection limit (7.2 μM) and shortest response time (30 s) among the reported Zn‐based probes to date, whereas the nitro group containing CP‐2 was unable to sense H2 S due to its framework disruption.