Acute Liver Failure in a Healthy Young Female With COVID-19. Issue 3 (22nd August 2021)

• Record Type: Journal Article
• Authors: Orandi, Babak John; Li, Geling; Dhall, Deepti; Bajpai, Prachi; Manne, Upender; Arora, Nitin; Lu, Ailing; Coronado, Ana Carolina; Kassel, Rachel; Pinninti, Swetha; Lewis, Cora Elizabeth; Chapleau, Christopher; Locke, Jayme Elizabeth; Gutierrez Sanchez, Luz Helena
• Is Part Of: JPGN reports. Volume 2:Issue 3(2021)
• Page Start: e108
• Publication Date: 2021-08-22
• Subjects: COVID-19 -- acute liver failure -- liver transplant; Pediatric gastroenterology -- Periodicals; Children -- Nutrition -- Periodicals; Children -- Nutrition; Pediatric gastroenterology; Infant Nutritional Physiological Phenomena; Child Nutritional Physiological Phenomena; Gastrointestinal Diseases; Infant; Child; Periodicals; Periodical; Case Reports; 618.9233
• DOI: 10.1097/PG9.0000000000000108
• Languages: English
• ISSNs: 2691-171X

Abstract

Abstract : Several well-described manifestations of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. Among them, a transient elevation of liver enzymes is the typical presentation of coronavirus disease 2019 (COVID-19) liver-related injury. The mechanism of liver involvement is likely a combination of viral injury and immune-mediated inflammation. In contrast, acute liver failure in the setting of COVID-19 has rarely been reported. Herein, we report a case of pediatric acute liver failure in a previously healthy female adolescent infected with SARS-CoV-2 with biopsy evidence of replicating virus in hepatocytes, which has not been previously reported.