Plasmon‐Enhanced Photocatalytic Activity of Organic Heterostructure for Indoor‐Light Antibacterial Therapy. Issue 2 (8th December 2021)

• Record Type: Journal Article
• Authors: Jiao, Hui‐Feng; Guo, Jiaxu; Cui, Yuying; Yu, Xin; Liao, Yunfei; Ying, Yiran; Li, Zhongan; Yao, Kai; Huang, Haitao
• Is Part Of: Advanced therapeutics. Volume 5:Issue 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-08
• Subjects: antibacterial efficacy -- cytotoxicity -- indoor light -- in situ implanting -- organic heterojunctions -- plasmonic nanocomposites; Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202100202
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract: Semiconductor nanomaterials with photocatalytic activity have been considered as potential antibacterial materials against bacterial infection. Noble metal nanoparticles have been developed with semiconductors to promote their photocatalytic activities; however, the incorporation of noble metal NPs brings the risk of toxicity from the heavy metal species, especially for the widely used Ag nanoparticles (AgNPs). Herein, an all‐organic chloridized g‐C3 N4 /perylene‐3, 4, 9, 10‐tetracarboxylic diimide (Cl‐CNPD) heterostructure is chosen as a platform, in which the chloridized g‐C3 N4 provides bonding sites for uniform loading of AgNPs to prepare a plasmonic antibacterial nanocomposite. Benefiting from the in situ implanting approach, plasmon‐induced light manipulation from the homodispersed AgNPs enables the nanocomposites to produce more reactive oxygen species (ROS), resulting in an antibacterial efficacy up to 96.1 ± 1.4% and 91.5 ± 1.8% against Staphylococcus aureus ( S. aureus ) under simulated sunlight (20 mW cm −2 ) and indoor light (5 mW cm −2 ) irradiation within 20 min, respectively, much higher than that of the organic heterostructure. Moreover, the strong interaction between the AgNPs and Cl‐CNPD not only guarantees negligible toxicity by minimizing Ag leakage, but also shows high durability with unchanged efficacy after challenging bacteria up to five times repeatedly. Therefore, this confined plasmonic‐based antibacterial nanocomposite shows great potential as a safe therapeutic system for wound disinfection. Abstract : Toward the development of cost‐effective and biocompatible antibacterial materials employing a photocatalytic therapy, we designed a plasmonic photocatalyst embedded with homodispersely distributed silver nanoparticles (AgNPs) through a precise in situ implanting approach. The strong interaction between metal nanostructures and the organic‐heterojunction platform enables the plasmonic nanocomposite to maintain a high durability of antibacterial efficacy, with low cytotoxicity, under indoor‐light irradiation.