Contact allergy to haptens in the Swedish baseline series: Results from the Swedish Patch Test Register (2010 to 2017). (10th November 2021)

• Record Type: Journal Article
• Authors: Andernord, Daniel; Bruze, Magnus; Bryngelsson, Ing‐Liss; Bråred Christensson, Johanna; Glas, Bo; Hagvall, Lina; Isaksson, Marléne; Matura, Mihály; Nyman, Gunnar; Stenberg, Berndt; Svedman, Cecilia; Lindberg, Magnus
• Is Part Of: Contact dermatitis. Volume 86:Number 3(2022)
• Page Start: 175
• Page End: 188
• Publication Date: 2021-11-10
• Subjects: contact allergy -- contact dermatitis -- eczema -- fragrance -- methylchloroisothiazolinone -- methylisothiazolinone -- nickel -- patch test -- preservative -- Sweden -- Swedish baseline series; Contact dermatitis -- Periodicals; 616.51
• DOI: 10.1111/cod.13996
• Languages: English
• ISSNs: 0105-1873

Abstract

Abstract: Background: Allergic contact dermatitis has considerable public health impact and causative haptens vary over time. Objectives: To report the prevalence of contact allergy to allergens in the Swedish baseline series 2010 to 2017, as registered in the Swedish Patch Test Register. Methods: Results and demographic information for patients tested with the Swedish baseline series in 2010 to 2017 were analysed. Results: Data for 21 663 individuals (females 69%) were included. Females had significantly more positive patch tests (54% vs 40%). The reaction prevalence rates were highest for nickel sulfate (20.7%), fragrance mix I (7.1%), Myroxylon pereirae (6.9%), potassium dichromate (6.9%), cobalt chloride (6.8%), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI; 6.4%), MI (3.7%), colophonium (3.5%), fragrance mix II (3.2%), and formaldehyde (3.2%). Myroxylon pereirae reaction prevalence increased from 5% in 2010 to 9% in 2017 and that for methyldibromo glutaronitrile from 3.1% to 4.6%. MCI/MI and MI reactions decreased in prevalence after 2014. Nickel reaction prevalence decreased among females aged 10 to 19 years. Conclusions: Nickel remains the most common sensitizing agent, with reaction prevalence decreasing among females younger than 20 years. The changes in MCI/MI and MI reaction prevalence mirrored those in Europe. The register can reveal changes in contact allergy prevalence over time among patients patch tested in Sweden. Abstract :