Brief Outlook on Polymeric Nanoparticles, Micelles, Niosomes, Hydrogels and Liposomes: Preparative Methods and Action. Issue 6 (8th February 2022)

• Record Type: Journal Article
• Authors: Joy, Reshma; George, Jinu; John, Franklin
• Is Part Of: ChemistrySelect. Volume 7:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-08
• Subjects: Drug Delivery -- Hydrogel -- Liposome -- Micelles -- Niosome -- Polymeric nanoparticles; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202104045
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Polymeric nanoparticles, micelles, niosomes, hydrogels and liposomes represent effective drug carriers having huge potential for medical and pharmaceutical applications. These systems remain the most important area in medicinal chemistry research. The aforementioned biomaterials can effectively encapsulate and release diverse hydrophobic/hydrophilic therapeutic molecules including drugs and prodrugs. Applications of these carrier systems extend to nucleic acids, antibodies and proteins which could be released sustainably. Since these systems fall in the nano dimension, they are capable of enhancing the therapeutic efficacy of bioactive molecules besides enabling them to accumulate preferentially at the target site. Furthermore, these systems can protect the encapsulated drug from degradation, thereby increasing the therapeutic value of the drug candidate and reducing systemic toxicity. In this review, we illustrate the preparative methods and actions of these five drug delivery systems. Abstract : Drug delivery systems (DDS) are carrier cargos employed to encapsulate drugs/prodrugs and bio macromolecules in medicinal chemistry applications. They can potentially control the release of therapeutic molecules into living cells. Polymeric nanoparticles, hydrogels, micelles, niosomes and liposomes represent drug delivery agents for efficient drug release. Smart drug carrier systems are highly warranted to overcome the hurdles in drug resistance and targeted drug delivery. Investigations to synthesize novel encapsulating systems with varying compositions by different synthetic routes may help to address the limitations of existing carriers in medicinal chemistry.