Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy. Issue 4 (27th November 2021)

• Record Type: Journal Article
• Authors: Ding, He; Chang, Jinhu; He, Fei; Gai, Shili; Yang, Piaoping
• Other Names: Hudalla Gregory A. guestEditor.
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-27
• Subjects: bioimaging -- biosafety -- cancer therapy -- gaseous signaling molecules -- hydrogen sulfide; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202101984
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Advances in nanotechnology have enabled the rapid development of stimuli‐responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H2 S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H2 S‐responsive properties, as new‐generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H2 S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H2 S. This review summarizes the state‐of‐art research on H2 S‐related nanomedicines. In particular, recent advances in H2 S therapeutics for cancer, such as H2 S‐mediated gas therapy and H2 S‐related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real‐time monitoring H2 S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H2 S‐based therapy that facilitate clinical translation to patients are discussed. Abstract : Hydrogen sulfide (H2 S) emerges as a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. The interdependent relationship between H2 S and its corresponding chemistry, biology, and nanotherapy leads to overview H2 S‐based gas therapy.