Euphorstranoids A and B, two highly rearranged ingenane diterpenoids from Euphorbia stracheyi: structural elucidation, chemical transformation, and lipid-lowering activity. Issue 3 (24th December 2021)

• Record Type: Journal Article
• Authors: Yuan, Fang-Yu; Pan, Yue-Hua; Yin, Ai-Ping; Li, Wei; Huang, Dong; Yan, Xue-Long; Wu, Shu-Qi; Tang, Gui-Hua; Pu, Rong; Yin, Sheng
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 3(2022)
• Page Start: 775
• Page End: 780
• Publication Date: 2021-12-24
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01705e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Euphorstranoids A (1 ) and B (2 ), two highly rearranged ingenane diterpenoids with an unusual 5/6/7/3 carbon ring system, were isolated from Euphorbia stracheyi . Abstract : Euphorstranoids A (1 ) and B (2 ), two highly rearranged ingenane diterpenoids with an unusual 5/6/7/3 carbon ring system, were isolated from Euphorbia stracheyi . Their structures were determined by a combination of spectral, chemical, and X-ray diffraction methods. The plausible biosynthetic pathway of 1 and 2 was proposed and chemically mimicked. Compounds 1 and 2 significantly inhibited the triglyceride (TG) level in 3T3-L1 adipocytes via retarding cell adipogenesis at the early stage.