Metal-free synthesis of N-sulfonylformamidines via skeletal reconstruction of sulfonyl oximonitriles. Issue 3 (17th December 2021)

• Record Type: Journal Article
• Authors: Li, Feng; Wu, Ziyan; Wang, Jingjing; Zhang, Siyuan; Yu, Jiaxin; Yuan, Zhen; Liu, Jingya; Shen, Renzeng; Zhou, Yao; Liu, Lantao
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 3(2022)
• Page Start: 627
• Page End: 632
• Publication Date: 2021-12-17
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01665b
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : We firstly develop an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline synthesis of N -sulfonylformamidines in decent to high yields under mild reaction conditions. Abstract : We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N -sulfonylformamidines in decent to high yields under mild reaction conditions. In addition, scale-up experiments and late-stage functionalization of drugs were also performed. Preliminary studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction.