The Effect of Catheterization on Susceptibility of Uropathogens After Pelvic Reconstructive Surgery. Issue 11 (November 2020)

• Record Type: Journal Article
• Authors: Baird, Rachael C.; Romich, Ellen; Holthaus, Emily; Barber, Matthew D.; Ferrando, Cecile A.
• Is Part Of: Female pelvic medicine & reconstructive surgery. Volume 26:Issue 11(2020)
• Publication Date: 2020-11
• Subjects: urinary tract infection -- catheterization -- uropathogens -- pelvic reconstructive surgery; Pelvis -- Diseases -- Periodicals; Pelvis -- Surgery -- Periodicals; Genital Diseases, Female -- surgery -- Periodicals; Urologic Diseases -- surgery -- Periodicals; Colonic Diseases -- surgery -- Periodicals; Rectal Diseases -- surgery -- Periodicals; Surgical Procedures, Operative -- methods -- Periodicals; 616.6
• DOI: 10.1097/SPV.0000000000000660
• Languages: English
• ISSNs: 2151-8378

Abstract

Abstract : Objective: The aim of this study was to determine whether bacterial uropathogens from positive urine cultures and uropathogen antibiotic susceptibility differ between catheterized (C) and noncatheterized (NC) patients after pelvic reconstructive surgery. Methods: This is a retrospective cohort study of patients with a positive urine culture within 1 year of pelvic reconstructive surgery. Patients were categorized as having an indwelling catheter placed for urinary retention or voiding dysfunction within 48 hours of specimen collection versus no catheter. Microbiology reports provided uropathogens and antibiotic susceptibility for each culture. Student t test, χ 2, and logistic regression were used to compare rates of non– Escherichia coli uropathogens and susceptibility to first-line antibiotics between C and NC groups. Results: A total of 427 positive urine cultures from 317 unique patients were identified. Positive urine cultures from C patients were less likely to contain E. coli (47.1% NC vs 29.2% C; P = 0.0009), with enterococcus being the most common non– E. coli uropathogen. The odds of non– E. coli uropathogens increased with age (adjusted odds ratio, 4.25; 95% confidence interval, 1.95–9.28; P = 0.0003 for the oldest patients). Cultures from C patients were more likely to have a uropathogen not susceptible to sulfamethoxazole/trimethoprim (20.5% NC vs 32.1% C; P = 0.03), nitrofurantoin (19.2% NC vs 34.6% C; P = 0.002), and cefazolin (18.1% NC vs 49.4% C; P < 0.0001). Conclusions: After pelvic reconstructive surgery, patients with a positive urine culture who have undergone catheterization within 48 hours of specimen collection are more likely to have non– E. coli uropathogens, with 1 in 3 cultures being not susceptible to common first-line antibiotics. This highlights the importance of performing susceptibility testing rather than treating empirically after pelvic reconstructive surgery.