Determination of β-Estradiol by Surface-Enhance Raman Spectroscopy (SERS) Using a Surface Imprinted Methacrylate Polymer on Nanoporous Biogenic Silica. (11th February 2022)

• Record Type: Journal Article
• Authors: Mugo, Samuel M.; Lu, Weihao
• Is Part Of: Analytical letters. Volume 55:Number 3(2022)
• Page Start: 378
• Page End: 387
• Publication Date: 2022-02-11
• Subjects: β-estradiol -- β-estradiol molecularly imprinted methacrylate polymers -- nanoporous biogenic silica (BS) -- surface enhanced Raman spectroscopy (SERS) -- surface polymerization; Chemistry, Analytic -- Periodicals; Chemistry, Analytic -- Abstracts; 543
• DOI: 10.1080/00032719.2021.1932969
• Languages: English
• ISSNs: 0003-2719

Abstract

Abstract: A phytoplankton derived nanoporous biogenic silica (BS) scaffold grafted with polymethacrylate β-estradiol molecularly imprinted polymers (MIP) film (MIP@BS) is reported as a selective platform for the determination of β-estradiol using surfaced-enhanced Raman scattering (SERS). The biogenic silica nanoparticles provided high surface area support for the MIP while serving as an active signal enhancement substrate for SERS. The MIP@BS platform demonstrated an excellent linear response (R 2 = 0.9996) between 0.1 and 4 ng/mL of β-estradiol standards. The limit of detection (LOD) for the MIP@BS SERS sensor for β-estradiol was 0.073 ng/mL. The MIP@BS SERS sensors were successfully evaluated for the determination of β-estradiol in milk, while demonstrating good stability and reusability.