E0024 Aldehyde dehydrogenase-2 G1951A gene polymorphism and drinking behaviour in males. (17th November 2010)

• Record Type: Journal Article
• Authors: Jing, Yang; Nanfang, Li; Tao, Li; Mei, Cao; Liang, Shao; Yonghua, Ma; Junli, Hu
• Is Part Of: Heart. Volume 96(2010)Supplement 3
• Page Start: A8
• Page End: A8
• Publication Date: 2010-11-17
• Subjects: Aldehyde dehydrogenase -- gene, polymorphism, alcohol consumption -- aldehyde; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.208967.24
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To study the distribution of genotypes about aldehyde dehydrogenase-2 (ALDH2 ) and its relationship with drinking behaviours in males. Methods: 226 males were enrolled for collecting blood samples and data about drinking behaviours. ALDH2 genotypes were detected by PCR-restriction fragment length polymorphism (PCR-RFLP). Results: 1. The frequency of ALDH2 G1951A mutant allele was 0.077; 2. The frequency of ALDH2 mutant genotypes (GA+AA) was significantly lower in males whose daily alcohol consumption ≥32.83 g (mean of daily alcohol consumption) than those of <32.83 g (p<0.05). Comparing with GG, the subjects with ALDH2 mutant genotypes (GA+AA) were significantly lower in alcohol consumption per occasion (Chinese white liquor), daily alcohol consumption and cumulative alcohol consumption, and had a shorter drinking years (p<0.05). Conclusion: ALDH2 G1951A Polymorphism was found in males of Xinjiang, and it was associated with drinking behaviour.