Bioreducible and pH-responsive shell crosslinked polymeric micelles from a star-shaped terpolymer as drug delivery system. Issue 7 (3rd May 2022)

• Record Type: Journal Article
• Authors: Motamedi, Sanaz; Massoumi, Bakhshali; Jaymand, Mehdi; Derakhshankhah, Hossein; Alizadeh, Effat
• Is Part Of: International journal of polymeric materials. Volume 71:Issue 7(2022)
• Page Start: 481
• Page End: 492
• Publication Date: 2022-05-03
• Subjects: ATRP -- cancer -- shell crosslinked nanocarrier -- stimuli-responsive micelles; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2020.1857382
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: Novel shell crosslinked (SCL) pH- and reduction-responsive micelles were fabricated through the grafting of DMAEMA and AA monomers onto a star-shaped PCL through ATRP followed by crosslinking with Cys. The chemical structures of the samples were investigated using 1 H NMR and FTIR. The developed micelles were loaded with MTX as an anticancer drug and their drug loading and encapsulation efficiencies were calculated to be 31.53 ± 0.3% for both. The fabricated drug delivery system (DDS) exhibited slow and stimuli-triggered drug release behavior. The anticancer performance of the DDS was examined using MTT assay against MCF7 cells. Graphical Abstract: UF0001