E0331 Effects of Shen Song Yang xin capsule for treatment of cardiac arrhythmia: a systematic review. (17th November 2010)

• Record Type: Journal Article
• Authors: Hao, Hu; Hai-Qin, Tang; Jie-Hua, Li; Lin-Lin, Yang; Wen-Juan, Tang; Zhong-Ran, Zhou
• Is Part Of: Heart. Volume 96(2010)Supplement 3
• Page Start: A103
• Page End: A103
• Publication Date: 2010-11-17
• Subjects: Shen Song Yang Xin Capsule -- propafenone -- mexiletine -- amiodarone -- anti-cardiac arrhythmia -- Meta-analysis; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.208967.331
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To evaluate the efficacy and safety of Shen Song Yang Xin Capsule for treatment of cardiac arrhythmia. Methods: Randomized controlled trials (RCTs) were searched from the following electronic databases: Wanfang, CNKI, CBM, Vip, PubMed, The Cochrane Library. Quality assessment and data extraction were conducted by two reviewers independently. Disagreement was resolved through discussion. All data were analysed by using Review Manager 5.0 software. Results: 13 studies involving 1896 participants involving. Meta-analysis results showed that, compared with control, (1) the efficacy, Shen Song Yang Xin Capsule is better than propafenone [RR=0.42, 95% CI (0.28 to 0.62)], mexiletine [RR=0.34, 95% CI (0.21 to 0.56)], no significant difference between Shen Song Yang Xin Capsule and amiodarone [RR=0.80, 95% CI (0.57 to 1.14)]. Total efficacy for treatment of cardiac arrhythmia is RR=0.54, 95% CI (0.42 to 0.68). (2) The safety, Shen Song Yang Xin Capsule is no worse than the control in inducing of cardiac arrhythmia [RR=0.06, 95% CI (0.02 to 0.15)], there is no significant difference between Shen Song Yang Xin Capsule and the control in inducing of gastrointestinal adverse reaction [RR=0.84, 95% CI (0.58 to 1.23)]. Conclusion: Compared with the current anti-arrhythmic medicine, Shen Song Yang Xin Capsule is no worse than the current anti-arrhythmic medicine, lower in the rate of inducing cardiac arrhythmia, and there is no significant difference between Shen Song Yang Xin Capsule and the current anti-arrhythmic medicine in inducing of gastrointestinal adverse reaction. For the restrictions of the quality of the studies, the evaluation of anti-arrhythmic effects look forward to more high-quality RCT to further evaluation.