Effects of rare earth-chitosan chelate on growth performance, antioxidative and immune function in broilers. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Cheng, Yuchen; Xie, Yi; Shi, Lulu; Xing, Yuanyuan; Guo, Shiwei; Gao, Yibiao; Liu, Zhengya; Yan, Sumei; Shi, Binlin
• Is Part Of: Italian journal of animal science. Volume 21:Issue 1(2022)
• Page Start: 303
• Page End: 313
• Publication Date: 2022-12-31
• Subjects: Rare earth-chitosan chelate -- broiler -- growth performance -- immune function -- antioxidant capacity; Animal culture -- Periodicals; Livestock -- Italy -- Periodicals; Veterinary medicine -- Italy -- Periodicals; Animal culture; Livestock; Veterinary medicine; Italy; Periodicals; Periodicals; 636.005
• DOI: 10.1080/1828051X.2022.2028589
• Languages: English
• ISSNs: 1828-051X

Abstract

Abstract: This research aims to study the effects of rare earth-chitosan chelates (RECC) on growth performance, immunity and antioxidant function in broilers. A total of 192 one-day-old mixed-sex Arbour Acres (AA) broilers were allotted into 4 treatment groups with 6 replicates per treatment and 8 broilers per pen. Broilers were fed the basal diet supplemented with, respectively, 0 (control group), 150, 200 and 250 mg/kg RECC for 42 d. The results showed that dietary RECC improved average daily gain and decreased feed/gain ( p < .05). Broilers fed with appropriate dose of RECC increased total antioxidant capacity (T-AOC) in serum (d 42) and liver (d 21). And the activity of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) were increased, whereas malonaldehyde (MDA) concentration was decreased on d 42 in liver of broilers ( p < .05) by enhancing the related gene expression in nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. In addition, supplementing appropriate dose of RECC in diet increased the concentrations of interleukin 2 (IL-2), IL-4 in serum and jejunum (d 42). And the concentrations of immunoglobulin M (IgM) (d 21), and secretory immunoglobulin A (sIgA), IgG (d 42) ( p < .05) in jejunum were elevated by decreased the related gene expression in Toll-like receptor 4/nuclear factor kappa-B (TLR4/NF-κB) pathway. In conclusion, RECC could exert beneficial effects on growth performance, immune function and antioxidant capacity of broilers, and the optimal supplemental dose for broiler production is 175 − 200 mg/kg. HIGHLIGHTS: This paper was very important in revealing the action mechanism of rare earth-chitosan chelate on immune function and antioxidant capacity of animals. The results of this study will provide a theoretical basis for further developing rare earth-chitosan chelate as antibiotic alternatives. The optimal dose range of rare earth-chitosan chelate in diet of broilers was 175–200 mg/kg.