E0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome. (17th November 2010)

• Record Type: Journal Article
• Authors: Dong, Hong-Mei; Huang, Lan; Song, Yao-Ming; Li, Ai-Min; Jin, Jun; Zhao, Gang; Lin, Chun-Mei; Tao, Chun-rong
• Is Part Of: Heart. Volume 96(2010)Supplement 3
• Page Start: A101
• Page End: A101
• Publication Date: 2010-11-17
• Subjects: Acute coronary syndrome -- probucol -- oxidative low density lipoprotein; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.208967.325
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy. Methods: 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months. Results: The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p<0.05), while the level of ox-LDL in peripheral blood in ACS patients was markedly diseased (p<0.01). The FMD with probucol treatment group was significantly increased compared to ACS routine treatment group (p<0.05), while the level of ox-LDL was markedly desaesed (p<0.01). The linear correlation analysis showed that plasma ox-LDL was a negative correlation with FMD in after treatmented patients by probucol with ACS (r=−0.517, p<0.001). Conclusions: It was important that vascular endothelial function and endothelial dependent vasodilation reaction may be improved in the ACS patients of after the antioxidant probucol therapy.