E0150 High frequency of peri-strut low intensity area assessed by optical coherence tomography after polymer-based sirolimus-eluting stents implantation in porcine model. (17th November 2010)

• Record Type: Journal Article
• Authors: Haibo, Jia; Jingbo, Hou; Jian, Wu; Maomao, Zhang; Hai, Qi; Xingtao, Huang; Huiming, Liu; Sining, Hu; Rong, Sun; Shuo, Zhang; Bo, Yu
• Is Part Of: Heart. Volume 96(2010)Supplement 3
• Page Start: A48
• Page End: A48
• Publication Date: 2010-11-17
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.208967.150
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objectives: To assess the frequency of peri-strut low intensity area (PLIA) in polymeric and nonpolymeric drug-eluting stents by optical coherence tomography (OCT) in porcine model, to analyse the pathological changes in PLIA. Setting: Previous intravascular ultrasound studies showed that black holes were more commonly seen in sirolimus-eluting stent restenosis. Similar phenomenon (peri-strut low intensity area) was also frequently detected by OCT in DES follow-up. However, it is still largely unknown what triggers this uncommon response. Design and interventions: A total of 18 stents (BMS, n=6; polymer-free PES [PF-PES], n=6 and polymer-based SES [PB-SES], n=6) were implanted in six minipigs and OCT was performed at 28 days after stenting. Stented arteries were harvested after terminal OCT imaging for pathological analysis. PLIA was defined as a region around stent struts with a homogenous lower intensity appearance than surrounding tissue on OCT images without significant signal attenuation behind the area. Results: At 28 days, PLIA was more frequently observed around the PBSES struts compared with PFPES and BMS struts (75% vs 33% vs 12%, respectively, p<0.001). Both in DES and BMS group, stents with PLIA showed significantly greater neointimal thickness than stents without PLIA (0.55±0.23 mm vs 0.13±0.08 mm, p<0.001). Histological results showed the existence of fibrin deposition and small amount of inflammatory cells at the site of PLIA. Conclusions: PBSES showed a higher incidence of PLIA compared with BMS and PFPES. PLIA may be related to fibrin deposition and vessel chronic inflammatory response to stent.